And so tragedy struck. While attacking the Antimonitor's stronghold, Superman and the new Doctor Light got cornered by the powerful villain. Supergirl came to the rescue and destroyed the Antimonitor's armor, but it came at a price... the girl of steel died in the arms of her cousin.
Once the heroes returned to Earth-One, a funeral was organized; people around the world said good bye for the last time to the brave superheroine. It was her best friend, Batgirl, who gave the eulogy.
After this, Supergirl was erased from history; but as if remembering this great loss deep inside her mind and her heart, Barbara eventually gave up her Batgirl mantle and so the damsel from Gotham was no more. Indeed, Crisis on Infinite Earths was a cosmic event as much as it was personal.